Dr. Mauricio Comas García

Nombre

Mauricio Comas García

Sección

Microscopía de Alta Resolución

Nacionalidad

Mexicana y Española

Estudios

• Licenciado en Química (UASLP)

• Doctorado en Química (UCLA)

• Posdoctorado (National Cancer Institute [NCI])

Contacto

correo electrónico: mauricio.comas@uaslp.mx

Facultad de Ciencias C416 Edificio 1 Ext. 5690

Puesto de Trabajo

Profesor de Tiempo Completo

Distinciones

SIN 1, Perfil PRODEP, Mejor Tesis de Doctorado en el Área Fisicoquímica 2013 (UCLA), Premio George Gregory 2012 a la mejor investigación en Fisioquímica (UCLA), Premio a la Docencia Académica 2009 (UCLA), Promedio más alto de la generaron 2007 de la Lic. en Química (UASLP).

Citas y artículos e índice h:

Citas: 817

Índice h: 12

Dirección de tesis concluidas

Terminadas:

• Miguel Angel Coronado-Ipiña, Licenciatura en Biología – “Ultrastructural characterization of the zika virus infection of human astrocytes derived from a human stem cell”. 2022

• Karen Airam Ortega-Palestino, Licenciatura en Biofísica – “Production, purification and characterization of non-infectious SARS-CoV-2 Virus-Like Particles”. 2022

• Arleth Miranda-López, Maestria Ciencias Farmacológicas –– Production, inactivation, and purification of Zika virus for its evaluation as a mucosal vaccine”. 2021

• Antonio Zúñiga-Izaguirre – Maestría en Ciencias Biomédicas Básicas – “In vitro assembly of Chikungunya virus and Zika virus”. 2021

• Pablo Antonio González. Licenciatura en Biología –“Generation of an in vitro assembly system of chikungunya virus capsid protein”. 2021

Líneas de investigación:

o Virología física y molecular: mecanismos de empaquetamiento y ensamblaje de virus de RNA de una sola hebra, desarrollo de vectores virales, y desarrollo de partículas pseudovirales

o Biología celular estructural: estudios ultraestructurales de los procesos de remodelación celular durante procesos infecciosos

o Desarrollo de candidatos vacunales: vacunas contra los virus SARS-CoV-2, Zika, y Chikungunya, basadas en partículas pseudovirales

Artículos publicados

1. León-Juarez, M., García-Cordero, J., Comas-García, M., Cedillo-Barrrón, L., González-Santamaria, J., & Shrivastava, G. (2022) Cellular, molecular and Immunological Aspects in Arboviruses Infection. Frontiers in Cellular and Infection Microbiology. 12:973953

2. Almendárez-Rodríguez, C., Solis-Andrade, K., Govea-Alonso, D., Comas-Garcia, M*. & Rosales-Mendoza, S*. (2022) Production and characterization of chimeric SARS-CoV-2 antigens based on the capsid protein of Cowpea chlorotic mottle virus. International Journal of Biological Macromolecules. 213, 1007-1017.

3. Comas-Garcia, M. (2022) The role of packaging signals in virus assembly and the interplay between the nucleation and elongation rates (New and Notable Article). Biophysical Journal. S0006-3495 (22) 00463-5

4. Farfán-Castro, S., García-Soto, M., Comas-Garcia, M., Arévalo-Villalobos, J., Palestino, G., González-Ortega, O., Rosales-Mendoza, S. (2021) Synthesis and immunogenicity assessment of a gold nanoparticle conjugate for the delivery of a peptide from SARS-CoV-2. Nanomedicine: Nanotechnology, Biology, and Medicine. 34, 102372.

5. Comas-Garcia, M., Colunga-Saucedo, M. & Rosales-Mendoza, S. (2020) The role of virus-like-particles in medical biotechnology. Molecular Pharmaceutics 17 (12), 4407-4420

6. Rosales-Mendoza, S. Comas-Garcia, M. & Korban, S.S. (2020) Challenges and Opportunities in Pursuing Science During the Coronavirus Pandemic. Trends in Biotechnology 38(8); 823

7. Comas-Garcia, M. (2019) Packaging of Genomic RNA in Positive-Sense Single-Stranded RNA viruses: A Complex Story. Viruses 11(3), 253 Selected as part of the special edition "Viruses 10-year anniversary".

8. Comas-Garcia, M., Kroupa, T., Datta, S.A.K., Harvin, D.P., Hu, W.S. & Rein, A. (2018) Efficient support of virus-like-particle assembly by the HIV-1 packaging signal. eLife 2018;7:e38438.

9. Comas-Garcia, M., Datta, S.A.K., Baker, L., Varma, R., Gudla, P.R. & Rein, A. (2017) Dissection of specific binding of HIV-1 Gag to the “packaging signal” in viral RNA. eLife 2017;6:e27055.

10. Comas-Garcia, M., Davis, S.R. Rein, A. (2016) On the selective packaging of genomic RNA of HIV-1. Viruses 8(9) 246.

11. Torres-Salgado, J.F., Comas-Garcia, M., Villagrana-Escareno, M.V., Duran-Meza, A., Ruiz-Garcia, J. & Cadena-Nava, R.D. (2016) Physicochemical study of viral nanoparticles at the Air/Water interface. The Journal of Physical Chemistry B 120(26):5864-5873.

12. Bruinsma, R.F., Comas-Garcia, M., Garmann, R.F. & Grosberg, A.Y. (2016) Quasi-equilibrium self-assembly of small RNA viruses. Physical Review E 93(3):032405.

13. Garmann, F.R., Comas-Garcia, M., Gopal, A., Knobler, C.M. & Gelbart, W.M. (2016) Physical principles in the self-assembly of a simple spherical virus. Accounts of Chemical Research 49(1): 48-55.

14. Garmann, F.R., Comas-Garcia, M., Koay, M.S.T., Cornelissen, J.J.L.M., Knobler, C.M. & Gelbart, W.M. (2014) Role of Electrostatics in the Assembly Pathway of a single-stranded RNA virus. Journal of Virology 88(18):10472-10479.

15. Comas-Garcia, M., Garmann, F.R., Singaram, S.W., Ben-Shaul, A., Knobler, C.M. & Gelbart, W.M. (2014) Characterization of viral capsid protein self-assembly around short single-stranded RNA. The Journal of Physical Chemistry B 118(27): 7510-7519.

16. Garmann, F.R., Comas-Garcia, M., Gopal, A., Knobler, C.M. & Gelbart, W.M. (2014) The assembly pathway of an icosahedral single-stranded RNA virus depends on the strength of inter-subunit attractions. The Journal of Molecular Biology 462(5):1050-1060.

17. Comas-Garcia, M., Cadena-Nava, R.D., Rao, A.L.N., Knobler, C.M. & Gelbart, W.M. (2012) In vitro quantification of the relative packaging efficiency of a single-stranded RNA molecules by viral capsid protein. Journal of Virology Volume 86, Number 22, 12271-12282

18. Cadena-Nava, R.D., Comas-Garcia, M., Garmann, R.F., Rao, A.L.N., Knobler, C.M., & Gelbart, W.M. (2012) Self-assembly of viral capsid protein and RNA molecules of different sizes: requirement for a specific high protein/RNA mass ratio. Journal of Virology Volume 86, Number 6, 3318-3326

Capítulos de libros:

1. García Silva, I.*, Colunga-Saucedo, M.*, Almendarez-Rodríguez, C., Miranda-López, C., Rosales-Mendoza, S., & Comas-Garcia, M. (2021) Chapter 10. VLP-based vaccines against SARS-CoV-2. Biomedical Innovations to Combat COVID-19 1st Ed. Elsevier. October 19th, 2021. ISBN 9780323902489

2. Comas-Garcia, M., Rubio-Hernández, E.I., Lara-Hernández, I., Colunga-Saucedo, M, Castillo, C.G., Comas-Garcia, A., Monsivais-Urenda, A., Zandi, R. (2021). Chapter 1. Basic virology aspects of SARS-CoV-2. Biomedical Innovations to Combat COVID-19 1st Ed. Elsevier. October 19th, 2021. ISBN 9780323902489

3. Lara-Hernández, I., Cornado-Ipiña, M.A., Rocha-Rosas, K., Comas-Garcia, M. (2021) Chapter 2. Fundamental aspects of the structural biology of Coronaviruses. Biomedical Innovations to Combat COVID-19 1st Ed. October 19th, 2021. ISBN 9780323902489

Libros Editados

• Rosales-Mendoza, S., Comas-García, M. Gonzalez-Ortega, O. Biomedical Innovations to Combat COVID-19 1st Ed. October 19th, 2021. Academic. Press ISBN 9780323902489