Dra. Diana Portales Pérez

​ ​ESTUDIOS

• Químico Farmacobiólogo (UASLP)
• Maestría en Biología Celular (UASLP)
• Doctorado en Ciencias Biomédicas Básicas (UASLP)

​DISTINCIONES

1. Sistema Nacional de Investigadores Nivel II.
2. Reconocimiento Perfil Deseable PRODEP.
3. Presea Rafael Nieto Compean 2017 por tiempo, dedicación y esfuerzo en actividades docentes.
4. Premio Universitario 2018, Investigador Consolidado modalidad Científica.
5. Co-autor en el Premio San Luis Potosí a la Investigación Científica y Tecnológica 2001 por el Gobierno del Estado de San Luis Potosí, la Secretaria de Educación de Gobierno del Estado y el Consejo Potosino de Ciencia y Tecnología.
6. Co-autor en el Premio VON BEHRING-KITASATO 2000 por la Academia Nacional de Medicina.
7. Co-autor en el Premio FUNSALUD 1998 Laboratorios Columbia en Dermatología por la Fundación Mexicana para la Salud.
8. Premio Sociedad Mexicana de Reumatologia-CIBA 1995, en Investigación Básica. 

​ARTICULOS PUBLICADOS EN REVISTAS INDIZADAS  POR JCR  (PubMed)

57

​​ARTICULOS PUBLICADOS EN LOS ULTIMOS 3 AÑOS EN REVISTAS INDIZADAS POR EL JOURNAL CITATION REPORTS (JCR)

2018

1.       Expression and genotype-dependent catalytic activity of N-acetyltransferase 2 (NAT2) in human peripheral blood mononuclear cells and its modulation by Sirtuin 1. Salazar-González RA, Turiján-Espinoza E, Hein DW, Milán-Segovia RC, Uresti-Rivera EE, Portales-Pérez DP. Biochem Pharmacol. 156 2018 340-347. Aug 24. pii:S0006-2952(18)30360-5. doi: 10.1016/j.bcp.2018.08.034. [Epub ahead of print] PubMed PMID: 30149019.

2.       Frequency of regulatory B cells in adipose tissue and peripheral blood from individuals with overweight, obesity and normal-weight. García-Hernández MH, Rodríguez-Varela E, García-Jacobo RE, Hernández-De la Torre M, Uresti-Rivera EE, González-Amaro R, Portales-Pérez DP. Obes Res Clin Pract. 2018 Aug 13. pii: S1871-403X(18)30058-9. doi: 10.1016/j.orcp.2018.07.001. [Epub ahead of print] PubMed PMID: 30115554.

3.       Increased Levels of AIM2 and Circulating Mitochondrial DNA in Type 2 Diabetes. Cataño Cañizales YG, Uresti Rivera EE, García Jacobo RE, Portales Perez DP, Yadira B, Rodriguez Rivera JG, Amaro RG, Enciso Moreno JA, García Hernández MH. Iran J Immunol. 2018 Jun;15(2):142-155. doi: IJIv15i2A7. PubMed PMID: 29947343.

4.       The inflammatory state of adipose tissue is not affected by the anti-inflammatory response of the A2a-adenosine system and miR-221/PTEN. Cortés-Garcia JD, Briones-Espinoza MJ, Vega-Cárdenas M, Ruíz-Rodríguez VM, Mendez-Mancilla A, Gómez-Otero AE, Vargas Morales JM, García-Hernández MH, Portales-Pérez DP. Int J Biochem Cell Biol. 2018 May 3;100:42-48. doi: 10.1016/j.biocel.2018.04.020. [Epub ahead of print] PubMed PMID: 29729889.

5.       A pilot study of the modulation of Sirtuins on Arylamine N-Acetyltransferase 1 and 2 enzymatic activity. Turiján-Espinoza Eneida, Salazar-González Raul Alejandro, Uresti-Rivera Edith Elena, Ortega-Juarez Montserrat, Hernandez-Hernandez Estela, Milan-Segovia Rosa del Carmen, Portales-Pérez Diana Patricia. Acta Pharm Sin B. 2018 Mar;8(2):188-199. doi: 10.1016/j.apsb.2017.11.008. Epub 2017 Dec 30.

6.       The presence of the 1068 G>A variant of P2X7 receptors is associated to an increase in IL-1Ra levels, insulin secretion and pancreatic β-cell function but not with glycemic control in type 2 diabetes patients. Edith Elena Uresti-Rivera, Rocío Edith García-Jacobo, José Alfredo Méndez-Cabañas, Laura Elizabeth Gaytan-Medina, Nancy Cortez-Espinosa, Diana Patricia Portales-Pérez, Roberto González-Amaro, José Antonio Enciso-Moreno, Mariana Haydee García-Hernández. Gene. 2018 Apr 30;652:1-6. doi: 10.1016/j.gene.2018.01.084. Epub 2018 Feb 6. PubMed. PMID: 29425823.

7.       Genetic polymorphisms of arylamine N-acetyltransferases 1 and 2 and the likelihood of developing pediatric acute lymphoblastic leukemia. Hernández-González Oswaldo, Ortiz-Zamudio Juan José, Rodríguez-Pinal Cristian Jazmín, Alvarado-Morales Ildemar, Martínez-Jiménez Verónica del Carmen, Salazar-González Raúl Alejandro, Correa-González Lourdes Cecilia, Portales-Pérez Diana Patricia, Milán-Segovia Rosa del Carmen. 2018 Aug;59(8):1968-1975. doi: 10.1080/10428194.2017.1406090. Epub 2017 Dec 7. PubMed PMID: 29214875.

8.       Arylamine N-acetyltransferase 1 in situ N-acetylation on CD3+ peripheral blood mononuclear cells correlate with NATb mRNA and NAT1 haplotype.  Raul A. Salazar-González, Eneida Turiján-Espinoza, David W. Hein, Perla C. Niño-Moreno, Silvia Romano-Moreno, Rosa C. Milán-Segovia, Diana P. Portales-Pérez. Arch Toxicol. 2018 Feb;92(2):661-668. doi: 10.1007/s00204-017-2082-y. Epub 2017 Oct 17. PMID:29043425

 

9.       miRNAs in nutrition, obesity and cancer: the biology of miRNAs in metabolic disorders and its relationship with cancer development. Portales-Pérez Diana. Mol Nutr Food Res. 2018 Jan;62(1) doi: 10.1002/mnfr.201600994. PMID: 28594107.

2017

10.   Tau protein in oral mucosa and cognitive state: A cross-sectional study. Luis Fernando Arredondo, Saray Aranda-Romo, Ildefonso Rodriguez-Leyva, Erika Chi-Ahumada, Sami K Saikaly, Diana Patricia Portales-Perez, Roberto Gonzalez-Amaro, Mariana Salgado-Bustamante, Lourdes Enriquez-Macias, William Eng, Robert Norman, Maria E. Jimenez-Capdeville, Front Neurol. 2017 Oct 13;8:554. doi: 10.3389/fneur.2017.00554. eCollection 2017. PMID:29081764

 

11.  FICZ generates human tDCs that induce CD4(+) CD25(high) Foxp3(+) Treg-like cell differentiation. Jurado-Manzano BB, Zavala-Reyes D, Turrubiartes-Martínez EA, Portales-Pérez DP, González-Amaro R, Layseca-Espinosa E. Immunol Lett. 2017 Jul. 29;190:84-92. doi: 10.1016/j.imlet.2017.07.013. [Epub ahead of print] PubMed PMID: 28765071.

12.   Analysis of transcription factors, microRNAs and cytokines involved in T lymphocyte differentiation in patients with tuberculosis after directly observed treatment short-course. Corral-Fernández Nancy Elizabeth, Cortes-García Juan Diego, Santiago-Rivas Bruno,  Romano-Moreno Silvia, Medellín-Garibay Susanna E, Magaña-Aquino Martín, Salazar-González R, González-Amaro Roberto, Portales-Pérez Diana Patricia. Tuberculosis (Edinb). 2017 Jul;105:1-8. doi: 10.1016/j.tube.2017.03.007. Epub 2017 Mar 28. PMID:28610780

 

13.   Exposure to p,p'-DDE Induces Morphological Changes and Activation of the PKCα-p38-C/EBPβ Pathway in Human Promyelocytic HL-60 Cells. Torres-Avilés NA, Albores-García D, Luna AL, Moreno-Galván M, Salgado-Bustamante M, Portales-Pérez DP, Calderón-Aranda ES. Biomed Res Int. 2016;2016:1375606. Epub 2016 Oct 19. PMID:27833915

 

14.   Toxicity evaluation of high-fluorescent rare-earth metal nanoparticles for bioimaging applications. Hernandez-Adame L, Cortez-Espinosa N, Portales-Pérez DP, Castillo C, Zhao W, Juarez ZN, Hernandez LR, Bach H, Palestino G. J Biomed Mater Res B Appl Biomater. 2017 Apr;105(3):605-615. doi: 10.1002/jbm.b.33577. Epub 2015 Dec 16. PMID:26671506

 

2016

15.  Two P2X1 receptor transcripts able to form functional channels are present in most human monocytes. López-López C, Jaramillo-Polanco J, Portales-Pérez DP, Gómez-Coronado KS, Rodríguez-Meléndez JG, Cortés-García JD, Espinosa-Luna R, Montaño LM, Barajas-López C. Eur J Pharmacol. 2016 Dec 15;793:82-88. doi: 10.1016/j.ejphar.2016.10.033. Epub 2016 Nov 5. PMID:27823931.

 

16.   Induction of transcription factors, miRNAs and cytokines involved in T lymphocyte differentiation in BCG vaccinated subjects. Corral-Fernández NE, Cortez-Espinosa N, Salgado-Bustamante M, Romano-Moreno S, Medellín-Garibay SE, Solis-Rodríguez M, Hernández-Castro B, Macías-Mendoza J,  González-Amaro R, Portales-Pérez DP. Mol Immunol. 2016 Jul 22;77:44-51. doi: 10.1016/j.molimm.2016.07.006.

17.   Diminished levels of regulatory T cell subsets (CD8+Foxp3, CD4+Foxp3 and CD4+CD39+Foxp3) but increased Foxp3 expression in adipose tissue from overweight subjects. Núñez Ruiz Aleida, Cortes-García Juan Diego, Cortez-Espinosa Nancy, Herrera-Rojas Paola Indira, Ruíz-Rodríguez Víctor Manuel, Salgado-Bustamante Mariana, García-Hernández Mariana Haydee, Reynaga-Hernández Elizabeth, Martínez-Jimenez Veronica del Carmen, Portales-Pérez Diana Patricia. Nutrition. 2016 Mar 4. Sep;32(9):943-54. doi: 10.1016/j.nut.2016.02.006. PMID: 27160497